Semler Scientific Review: Bitcoin Reserves & PAD Solutions



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Semler Scientific is an American medical technology company specializing in innovative healthcare solutions such as the QuantaFlo® System for diagnosing peripheral arterial disease (PAD). In 2024, the company adopted a strategy of holding reserves in Bitcoin, acquiring more than 1 800 BTC.
Semler Scientific medical technology is building a strong presence at the intersection of healthcare and finance. The company develops advanced tools for chronic disease diagnostics, including QuantaFlo®, a system designed for peripheral artery disease test at home.
Besides its technological progress, Semler Scientific takes a unique financial approach by holding reserves in Bitcoin, considering it a way to secure capital. This strategy helps the company stand out from typical healthcare companies. In this article, we’ll take a closer look at its operations, financial strategies, and future plans.
Semler Scientific overview
General information about Semler Scientific:
Type of business. Semler Scientific medical technology helps healthcare professionals deliver better patient care through innovative solutions. Its main product, QuantaFlo®, is a quick, four-minute, in-office test that helps doctors check patients’ vascular health by measuring blood flow. This breakthrough Semler Scientific healthcare innovation showcases the company’s innovative approach to healthcare.
Region of operations. The Company is based in Santa Clara, California, and operates primarily in the United States.
Market capitalization. Semler Scientific's market capitalization is approximately $500 million.
Semler Scientific healthcare innovation. QuantaFlo®, is a patented, FDA-cleared product for measuring arterial blood flow in the extremities that provides results in minutes. It is used to diagnose peripheral arterial disease (PAD) and helps healthcare professionals more fully assess patients' risk for heart attacks and strokes.
Founder. Semler Scientific was founded in 2007 by Dr. Herbert J. Semler, who also serves as the company's Chairman Emeritus.
Semler Scientific history
Semler Scientific was founded in 2007 with the goal of developing innovative medical technologies for the early diagnosis of chronic diseases. In 2011, the company introduced its flagship product, QuantaFlo®, for non-invasive testing of peripheral arterial disease (PAD). This tool allows healthcare professionals to quickly and accurately assess blood flow in the extremities, which facilitates the early detection of PAD.
In May 2024, Semler Scientific Bitcoin holdings strategy was introduced, starting with 581 BTC worth $40 million. By December 2024, its Bitcoin holdings rose to 1,873 BTC, valued at approximately $147.1 million. This approach aims to spread risk and combat inflation.
During Q3 2024, Semler Scientific reported $13.5 million in revenue, a 17% year-on-year decline. However, net income rose to $5.6 million, showing steady business performance.
Semler Scientific stock is traded on NASDAQ under the ticker SMLR and is tradable through U.S.-linked brokerage platforms. The company develops cutting-edge medical technologies while using smart financial strategies to maintain its strong market presence.
Interesting facts
Semler Scientific shares surged 29% after announcing its first Bitcoin purchase (WSJ).
The company continues to develop QuantaFlo®, aiming to expand its use in cardiovascular disease diagnostics.
The company's Bitcoin investments are part of a strategy to ensure a reliable asset reserve.
Semler Scientific Bitcoin holdings
Semler Scientific, a healthcare technology company, has adopted a Bitcoin-focused treasury strategy and has actively expanded its Bitcoin holdings in 2024. The company holds 1,873 Bitcoin, acquired at an average price of $78,553 per Bitcoin, for a total investment of approximately $147.1 million. The most recent purchase of 303 Bitcoin cost $29.3 million, averaging $96,779 per coin.
Semler Scientific funds its Bitcoin acquisitions through proceeds from at-the-market (ATM) stock offerings, allowing it to preserve operational cash while building its Bitcoin position. The company measures its strategy's effectiveness using a proprietary metric called "BTC Yield," which evaluates the ratio of Bitcoin holdings to diluted shares outstanding. This approach aligns with their view of Bitcoin as a digital gold-like asset. The company’s growing Bitcoin reserves place it among the top public firms holding Bitcoin, reflecting a broader corporate trend toward using cryptocurrency as a treasury reserve asset.
Semler Scientific stock
Semler Scientific, Inc. (NASDAQ: SMLR) is currently trading with a stock price fluctuating around $21–72 in 2024. The stock has shown significant volatility, driven partly by the company’s dual focus on its core healthcare innovation business and its recent Bitcoin treasury strategy.

Factors influencing the stock
Core business. Semler’s flagship product, QuantaFlo®, for detecting Peripheral Arterial Disease (PAD), continues to drive revenue. This FDA-cleared diagnostic system has a growing market, supported by increased demand for cardiovascular health solutions.
Bitcoin holdings. The company’s adoption of a Bitcoin treasury strategy, holding 1,873 BTC valued at over $189 million, has contributed to both market enthusiasm and risks due to cryptocurrency volatility.
Insider activity. Some insider sales were reported in December 2024, which may indicate profit-taking or adjustments in leadership holdings.
Semler Scientific combines cutting-edge healthcare and bold financial decisions
Semler Scientific healthcare innovation combines cutting-edge healthcare and bold financial decisions. While its use of Bitcoin as a reserve asset draws interest, its product development is more critical to healthcare providers and investors. QuantaFlo®, a tool for peripheral artery disease test at home, can help cut long-term treatment expenses. According to the American Heart Association, timely PAD diagnosis can reduce the risk of amputation by 48% and trim treatment costs by 35%. These metrics influence healthcare providers and investors when evaluating QuantaFlo®’s potential.
With rising demand for at-home PAD testing, Semler Scientific could expand its reach into the B2C market. New partnerships with telemedicine platforms and insurers could facilitate home-based testing. This move would open a new chapter in the growth of Semler Scientific medical technology, strengthening its foothold in the market.
Investors tracking Semler Scientific stock should watch for potential blockchain integration for securing and managing medical data. Although this development has not yet appeared in company reports, it could emerge as a valuable strategy amid growing demand for digital healthcare solutions. The company’s steady financial performance and innovative products make it a promising long-term investment in 2025.
Conclusion
Semler Scientific successfully combines medical technology with financial innovation, strengthening its position in the market. The QuantaFlo® product facilitates rapid and affordable diagnostics of peripheral arterial disease, which reduces risks for patients and reduces treatment costs. The company's strategy of using Bitcoin holdings as a reserve asset demonstrates flexibility in managing financial resources and protection from economic instability. The introduction of new partnerships and possible integration of blockchain technology may be the next stages of the company's growth. Semler Scientific stock is of interest to investors focused on healthcare and long-term investments. Continuing its innovative approach will allow the company to remain competitive at the intersection of medicine and finance.
FAQs
What is peripheral artery disease (PAD)?
PAD is a circulatory condition where narrowed arteries reduce blood flow to the limbs, often leading to leg pain and increasing the risk of cardiovascular events. Early detection is crucial for effective management.
How does QuantaFlo® assist in PAD detection?
QuantaFlo® is a non-invasive test that measures blood flow in the extremities, providing immediate results to help healthcare providers diagnose PAD and assess the risk of related complications.
Why did Semler Scientific choose Bitcoin as a treasury reserve asset
The company views Bitcoin as a reliable store of value and a compelling investment, anticipating significant returns as it gains acceptance as "digital gold."
Is Semler Scientific integrating blockchain technology into its medical products?
As of now, there is no indication that Semler Scientific is incorporating blockchain technology into its medical software or devices. The company's engagement with Bitcoin is primarily for treasury management purposes.
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Team that worked on the article
Maxim Nechiporenko has been a contributor to Traders Union since 2023. He started his professional career in the media in 2006. He has expertise in finance and investment, and his field of interest covers all aspects of geoeconomics. Maxim provides up-to-date information on trading, cryptocurrencies and other financial instruments. He regularly updates his knowledge to keep abreast of the latest innovations and trends in the market.
Chinmay Soni is a financial analyst with more than 5 years of experience in working with stocks, Forex, derivatives, and other assets. As a founder of a boutique research firm and an active researcher, he covers various industries and fields, providing insights backed by statistical data. He is also an educator in the field of finance and technology.
As an author for Traders Union, he contributes his deep analytical insights on various topics, taking into account various aspects.
Mirjan Hipolito is a journalist and news editor at Traders Union. She is an expert crypto writer with five years of experience in the financial markets. Her specialties are daily market news, price predictions, and Initial Coin Offerings (ICO).
Forex leverage is a tool enabling traders to control larger positions with a relatively small amount of capital, amplifying potential profits and losses based on the chosen leverage ratio.
Volatility refers to the degree of variation or fluctuation in the price or value of a financial asset, such as stocks, bonds, or cryptocurrencies, over a period of time. Higher volatility indicates that an asset's price is experiencing more significant and rapid price swings, while lower volatility suggests relatively stable and gradual price movements.
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Yield refers to the earnings or income derived from an investment. It mirrors the returns generated by owning assets such as stocks, bonds, or other financial instruments.
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