Allogene Therapeutics advances early LBCL intervention with integrated ALPHA3 trial

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Mykhailo Ihnatenko

02.10.2026

Allogene Therapeutics advances early LBCL intervention with integrated ALPHA3 trial — Allogene launches ALPHA3 LBCL trial

Allogene Therapeutics is integrating investigational minimal residual disease (MRD) testing technology with its off-the-shelf CAR T cell therapy in the ALPHA3 trial targeting large B-cell lymphoma (LBCL).

The company aims to intervene earlier in the treatment pathway for LBCL, where one in three patients experience cancer recurrence after first-line therapy. This trial is designed to potentially improve cure rates among these patients.

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