Allogene Therapeutics ALPHA3 trial explores allogeneic CAR T potential in LBCL treatment

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05.05.2026

Allogene Therapeutics ALPHA3 trial explores allogeneic CAR T potential in LBCL treatment — Allogene tests ALPHA3 for LBCL

Allogene Therapeutics is advancing research into allogeneic CAR T therapy through its ALPHA3 clinical trial, aiming to transform treatment options for patients with large B-cell lymphoma (LBCL).

Dr. Zachary Roberts, EVP of R&D and CMO at the company, discussed the potential impact of this new approach in a recent interview with John Cendpts for the Endpoints News R&D 15 series. This research could represent a major development in cell therapy, offering hope for improved outcomes in a patient group often facing limited alternatives.

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Allogene Therapeutics previously advanced its investigational AlloCAR T therapy to improve treatment speed, scalability, and patient access, according to a company update. The firm also recently launched ALLO-329, a novel allogeneic CAR-T cell therapy targeting autoimmune diseases with Dagger technology, as detailed in an earlier announcement. The company continues to diversify its pipeline in cell therapy.

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