Allogene Therapeutics pursues early cancer relapse detection in LBCL with ALPHA3 trial integrating MRD testing

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Artem Shendetskii

08.07.2026

Allogene Therapeutics pursues early cancer relapse detection in LBCL with ALPHA3 trial integrating MRD testing — Allogene targets early LBCL relapse

One in three patients with large B-cell lymphoma (LBCL) experience cancer recurrence after receiving first-line treatment, according to Allogene Therapeutics.

The company is advancing its ALPHA3 clinical trial, which combines investigational minimal residual disease (MRD) testing technology and an off-the-shelf CAR-T product, aiming to enable earlier intervention and potentially improve cure rates for patients. The ALPHA3 study seeks to address a critical unmet need by using MRD diagnostics to identify relapses sooner in the treatment process.

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Allogene is pursuing wider access to off-the-shelf CAR T cell therapy for LBCL patients with early ALPHA3 trial results, according to a previous report. The company aims to expand the reach of CAR T technology through its investigational AlloCAR T platform, as detailed in an earlier announcement. Both initiatives focus on developing alternatives to autologous CAR T treatments.

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