Sequencing constraints lifted as Pacific Biosciences of California enables combined genetic and methylation detection

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Yaroslav Dmytrenko

19.05.2026

Sequencing constraints lifted as Pacific Biosciences of California enables combined genetic and methylation detection — Pacific Biosciences advances sequencing

Pacific Biosciences of California announces a technology advancement allowing researchers to capture both genetic variation and native methylation in a single sequencing run without additional preparation.

This development, powered by the company’s HiFi sequencing platform, aims to streamline data collection and overcome traditional trade-offs in genomic analysis. The new method could accelerate genetic research and offer more comprehensive insights for clinical and scientific applications.

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Pacific Biosciences previously kicked off its PacBioPRISM tour finale in Japan, highlighting new research and advancements in HiFi sequencing technology. The company has also promoted whole genome sequencing as a future standard for newborn care. These moves reflect Pacific Biosciences’ ongoing efforts to expand the applications of its sequencing platforms.

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