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Spyre Therapeutics investigates SPY003 as innovative monotherapy and combination approach

Spyre Therapeutics investigates SPY003 as innovative monotherapy and combination approach
Spyre Therapeutics develops SPY003 antibody

Spyre Therapeutics is advancing research on SPY003, a long-acting investigational antibody designed to target IL-23, an inflammatory pathway linked to the progression of inflammatory bowel disease (IBD).

The company is evaluating SPY003 both as a monotherapy and in combination therapies, underscoring ongoing innovation toward addressing pro-inflammatory T cell expansion in IBD.

Spyre Therapeutics recently secured $350 million in new funding for late-stage development, bringing its total capital to over $2 billion, according to a financing update. The company has also presented new clinical and preclinical data on SPY001, SPY002, and SPY003, including findings on additive efficacy in IBD combination therapies at UEGW2026. The portfolio expansion reflects ongoing investment in IBD research.

This material may contain third-party opinions, none of the data and information on this webpage constitutes investment advice according to our Disclaimer. While we adhere to strict Editorial Integrity, this post may contain references to products from our partners.

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