Pacific Biosciences of California introduces HiFi sequencing to unlock epigenome and chromatin mapping

Pacific Biosciences of California introduces HiFi sequencing to unlock epigenome and chromatin mapping
Pacific Biosciences HiFi sequencing launch

Pacific Biosciences of California announces a new single-run HiFi sequencing technology designed to capture the active epigenome and map chromatin architecture rapidly.

The company highlights the platform’s ability to decode CHG and CHH methylation in plants, detect animal 5hmC, and deliver architecture insights using Fiber-seq within a single workflow. This integrated approach opens new dimensions in genomics research, offering scientists a more complete picture beyond DNA sequences alone.

Pacific Biosciences has recently introduced its Ampli-Fi workflow to support HiFi sequencing using lower DNA input for laboratory settings. The company also attracted significant attention at ESHG2026 with well-attended sessions and booth events during the conference’s final days. These developments come as PacBio expands its technology portfolio within the genomics sector.

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