Verastem, Inc. initiates first dosing in Phase 2 trial for KRAS G12D pancreatic cancer therapy

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Parshwa Turakhiya

17.06.2026

Verastem, Inc. initiates first dosing in Phase 2 trial for KRAS G12D pancreatic cancer therapy — Verastem starts Phase 2 cancer trial

Verastem, Inc. has announced the first patient dosing in its TARGET-D 201 Phase 2 registration-directed trial. The study focuses on evaluating VS-7375, an investigational oral inhibitor targeting KRAS G12D mutations in patients with metastatic pancreatic cancer.

The commencement of patient enrollment is a pivotal step in assessing new therapeutic options for a cancer type with limited treatment choices. The TARGET-D 201 trial is designed to determine the efficacy and safety of VS-7375 in a population with high unmet medical needs.

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Verastem previously secured U.S. FDA Fast Track status for its KRAS G12D inhibitor in the treatment of non-small cell lung cancer, according to a company announcement. The company also recently outlined preliminary updates for its KRAS G12D clinical program during an investor conference. These developments highlight Verastem’s continued focus on advancing therapies for cancers with high unmet need.

This material may contain third-party opinions, none of the data and information on this webpage constitutes investment advice according to our Disclaimer. While we adhere to strict Editorial Integrity, this post may contain references to products from our partners.

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