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Pacific Biosciences of California advocates for using hybrid capture in targeted HiFi sequencing, especially when working with larger panels, custom target designs, or shifting from short-read workflows.
The company underscores that this approach enables comprehensive variant detection and phasing, supporting advanced genomics research. Pacific Biosciences of California directs users to learn more about these applications to maximize sequencing efficiency and accuracy.
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Pacific Biosciences of California previously analyzed performance differences between Illumina TruPath and PacBio HiFi WGS, focusing on benchmarking, variant calling, and phasing in a comparison using the HG002 benchmark (see article). The company was also featured in a Cell special issue that highlighted 13 new complete genome assemblies enabled by its technology (see article). These developments reflect the company's continued efforts in advancing genomics research and sequencing technology.